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Science (2021) 371(6528):eabd0811

It originally came from the gut

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These findings underscore the necessity of maintaining balanced dietary habits and adequate nutrient intake to preserve commensal stability and maintain epithelial and immune homeostasis

Although primarily known as a pro-inflammatory cytokine that binds to cell membrane receptors to potentiate intracellular signaling 45 , eNAMPT can also be taken up by cells such as neurons and increase NAD + synthesis 46

Its relevance to mood disorders stems from broad neurotrophic effects, including BDNF modulation and neuroprotection