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From an immunological perspective, these associations arise from a breakdown in self-tolerance mediated by overlapping T-cell and B-cell autoreactivity, shared cytokine pathways (e.g., IFN-, IL-18), and common antigen-presenting HLA alleles

PMID 28866346

Occasional mild fatigue may occur early in treatment but usually improves with continued use

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4 weeks 2 vials Roughly one vial every two weeks

However, the effects of prolonged exposure to this medicine on different organ systems and possible cumulative impact require further investigation