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doi: 10.1523/JNEUROSCI.2689-13.2014

Abstract Nicotinamide adenine dinucleotide (NAD + ) and its metabolites function as critical regulators to maintain physiologic processes, enabling the plastic cells to adapt to environmental changes including nutrient perturbation, genotoxic factors, circadian disorder, infection, inflammation and xenobiotics

In clinical trials, the most common adverse effects were gastrointestinal, including nausea, vomiting, diarrhea, and constipation

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Therapeutic targeting of glutamate dehydrogenase 1 that links metabolic reprogramming and Snail-mediated epithelialmesenchymal transition in drug-resistant lung cancer