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In ER+ models, MCF-7 cells were more resistant to RSL3 compared to T47D cells (Fig

Additional details on datasets and protocols that support the findings of this study will be made available upon reasonable request by the corresponding author

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Using these enzyme preparations with a defined GSH concentration (20 M) in the established two-step in vitro reactions, we found that the extent of conversion of the ultrafiltered flavan-3,3,4-triol ( 4 ) depended on the applied concentration of the purified Pt GSTF8, confirming that this enzyme is required and sufficient for the observed conversion to cyanidin (Extended Data Fig