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71 Interestingly, metabolite profiling of cells treated with Cu ionophore presents a time-dependent increase in the dysregulation of many TCA cycle-associated metabolites, and inhibiting the electron transport chain complexes I and II significantly reduced Cu-induced cell death

Figure 6 - Disease in case of uncontrolled oxidative stress (adapted from Lykkesfeldt & Svendsen, 2007)

The mitochondrial Cu(+) transporter PiC2 (SLC25A3) is a target of MTF1 and contributes to the development of skeletal muscle in vitro

Responses to a 2014 survey of 889 patients with pernicious anaemia revealed that up to 92% of patients notice a return of their symptoms before their next dose is due[28]

Siska, P

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