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Disruption of oxidative homeostasis in the cardiovascular system can lead to oxidative stress, causing cellular damage and cardiovascular disease (38)

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Patients with known heart disease or risk factors appear to have a greater likelihood of an event following NSAID use, likely due to a higher baseline risk

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Subedi P, Moertl S, Azimzadeh O

Analysis of mutations in the XPD gene in Italian patients with trichothiodystrophy: site of mutation correlates with repair deficiency, but gene dosage appears to determine clinical severity