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Nonetheless, clinical trials involving both healthy individuals and those with mild cognitive impairment or AD are warranted to investigate whether melatonin can enhance the glymphatic systems efficacy in reducing brain concentrations of A and tau

This work was supported by the United Arab Emirates University (UAEU) Strategic Research Program 2024 grant (proposal number 3702

The observed accumulation of GSH in Sp treated cells was probably due to reduced activity of -glutamyl transpeptidase (GGT), an enzyme responsible for glutathione catabolism 36

Western Blot Samples were suspended in lysis buffer (250 mM Sucrose, 50 mM Tris pH 7.4, 1 MgCl, and 0.2 % (v/v) Triton X-100)

Wang D, Tang L, Wu Y, Fan C, Zhang S, Xiang B, et al

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