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In a placebo-controlled Phase 3 clinical trial, four weeks after receiving bardoxolone methyl, patients with T2D and stage 4 chronic kidney disease had elevated serum levels of the liver injury markers -glutamyl transferase, aspartate aminotransferase (AST), and alanine aminotransferase (ALT)

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The western blot results indicated that overexpression of SLC38A5 markedly enhanced the levels of p-PI3K, p-AKT and p-mTOR in osteosarcoma cells (Fig

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