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894 Acid sphingomyelinase (ASM)-mediated autophagy activation is critical for hyperglycemia -induced GPX4 degradation, and inhibition of ASM improves osteogenic function by reducing hyperglycemia-induced GPX4 degradation and subsequent ferroptosis
Copper ions delivered by GHK-Cu also demonstrate up to 90% inhibition of type 1 5-alpha reductase at specific concentrations
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Coffee stimulates gastrin (a hormone that stimulates the secretion of gastric acid), gastric acid secretion, and gallbladder contraction, all of which have an impact on our gastrointestinal tract
TGF-1 is an important cytokine that induces fibrosis in organs such as the kidneys and lungs [39, 40], and can activate PSCs to induce pancreatic fibrosis [41, 42]
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