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In several previously published studies, Pycnogenol was shown to improve circulation in small blood vessels in the body, like the very fine micro vessels in the fingertips or in the retinal capillaries of the eye (31, 46)

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Approximately four ml of blood were obtained via jugular venipuncture at every time point

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Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-B/IL-8 pathway that drives tumor angiogenesis