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Tetrahydrobiopterin (BH 4 ) plays a vital role in this reaction by stabilizing the eNOS dimer and preventing the formation of superoxide, a potentially harmful byproduct, ensuring NO synthesis proceeds efficiently (Xia et al., 1998a

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Furthermore, we could identify a SASP gene expression profile (senescence-associated secretory phenotype) 39,40 after TBI (Supplementary Fig

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In cancer, antifolate drugs that inhibit key enzymes of folate-dependent 1C metabolism and strategies targeting folate receptors are current therapeutic options