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Archived from the original on February 26, 2017

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Abbreviations ATMP: Advanced therapeutic medicinal product CHMP: Committee for medicinal products for human use COMP: Committee for orphan medicinal products DFS: Disease-free survival EFS: Event-free survival EC: European Commission EMA: European medicines agency EPAR: European public assessment report EU: European Union EUMRN: EU medicines regulatory network FEV: Forced expiratory volume ITT: Intention-to-treat population MAA: Marketing authorization application MAH: Marketing authorization holder MS: Member state ODD: Orphan drug designation OMAR: Orphan maintenance assessment report OMP: Orphan medicinal product ORR: Objective response rate OS: Overall survival pCR: Pathological complete response PFS: Progress-free survival PRAC: Pharmacovigilance Risk Assessment Committee PRIME: Priority medicines RCT: Randomized controlled trials RWD: Real world data RWE: Real world evidence SME: Small and medium sized enterprises US: United States References Regulation (EC) No 141/2000 of the European Parliament and of the Council of 16 December 1999 on orphan medicinal products

The aim of the present clinical and histological study is to determine the efficacy of an injectable solution containing sodium salt of ascorbic acid 0.24% and surfactant agent at 0.020% ascorbyl-palmitate (SAP) for treating local adiposity

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Como resultado, hay un aumento crnico en los niveles de azcar en la sangre y un riesgo significativamente mayor de complicaciones como el sndrome del pie diabtico, la nefropata diabtica o la angiopata diabtica