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These resistant cells upregulate lipid ROS-detoxifying enzymes such as GPX4 and FSP1, and knockdown of GPX4 in these resistant cells re-sensitizes them to both ferroptosis and TMZ [155], highlighting a glioblastoma-specific therapeutic vulnerability that emerges from alkylating agent adaptation

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Infiltrating immune cells either exhibit anticancer responses or create an immunosuppressive environment (105)

#2577, Cell Signaling Technology, Danvers, MA) overnight at 4C, followed by incubation with Alexa Fluor 594-labelled donkey anti-rabbit IgG (1:300

Its chemical sources mainly include the following raw materials: 1