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Early clinical studies at the University of Arizona demonstrated dose-dependent increases in skin pigmentation without UV exposure, along with side effects including nausea and facial flushing at higher doses

ACTH- and alpha-MSH-induced grooming, stretching, yawning and penile erection in male rats: Sites of action in the brain and role of melanocortin receptors

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It glides on the lips easily and offers layerable coverage

J Mol Endocrinol (2012) 48:193202

Prescribers should base decisions on clinical necessity and monitor both mother and infant when use during lactation is unavoidable