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Interestingly, despite lupus patients commonly having anemia, their T cells exhibit high iron levels

NTCP and BSEP, key bile acid transporters, show therapeutic relevance in liver diseases

In eighteen relevant perioperative NAC meta-analyses, nine investigated the effect of NAC on renal function in cardiac surgery as the primary objective [33,35,37,38,41,44,47,48,66], three discussed general NAC use in cardiac surgery with frequent mention of renal outcomes [40,45,49], and two focused on renal outcomes in noncardiac surgery [43,46]

However, these studies assume a linear pathway of action, but the complexity of ROS-mediated pathways and the potential for off-target effects in humans remains to be fully elucidated