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Histone acetylation is related to open chromatin structure and transcriptional activation (Mali et al., 2010)

This study has several limitations: (1) The experimental findings are derived from an SD rat model, and species-specific differences in ICH pathophysiology necessitate validation in large animal models (e.g., porcine or non-human primates) to confirm translational relevance

Although DIA reduces these issues, it introduces increased computational complexity and reliance on robust data analysis pipelines

It has been reported that as the length of the tag increases, a negative effect on cellular growth, stability of the plasmids, secretion efficiency of the target protein and a decrease of recovery yield on purification stage are observed (Lienqueo et al., 2008)

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