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These results suggest that NRF2 serves as a biomarker for predicting ferroptosis by targeting LDHB and SLC7A11 in KRAS -dependent cancer cells, consistent with previous finding that LDHB plays a unique role in KRAS-mutant lung cancer [27, 56]

doi: 10.3390/antiox12030615 92 QanashHBazaidASBinsalehNKPatelMAlthomaliOWSheehaBB

3.2.1 Hirudin Hirudin is a primary active component derived from the medicinal leech ( Hirudo medicinalis Linnaeus, belonging to the Hirudinidae family), exhibiting anticoagulant, antifibrotic, antithrombotic, and anti-inflammatory properties, and demonstrating significant protective effects on the kidneys ( Initially, in the realm of metabolic regulation, research has demonstrated that hirudin can lower blood sugar levels and glycated hemoglobin in a rat model of DKD induced by a high-fat, high-sugar diet combined with streptozotocin (STZ)

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Because it is a small molecule that passively diffuses across the intestinal lining, it does not rely heavily on microbial metabolism in the gut

Iommiello, V