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It is characterised by genetic and autoimmune components, with hyperactivation of the immune system and an inflammatory cycle that self-sustains developing around the TNF/IL-23/IL-17 axis [47]

In lean healthy individuals, adiponectin and resistin were normally secreted from WAT to regulate homeostasis in insulin sensitivity

Furthermore, MSM can regulate the balance between ROS and antioxidant enzymes by controlling other signaling pathways: Janus kinase/signal transducer and activator of transcription [40,41], nuclear factor (erythroid-derived 2)-like 2, and phosphoinositide 3-kinase/protein kinase B [37]

Uteroplacental insufficiency causes microbiota disruption and lung development impairment in growth-restricted newborn rats

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