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Analyst 140, 54885494

Origins as a Mitochondrial-Derived Peptide MOTS-C peptide was first characterized in 2015 by Lee and colleagues, who showed that stressed muscle cells release this peptide, which then translocates to the nucleus to upregulate genes involved in adaptive stress resistance

Analogs targeting arginase and arginine deiminase, the enzymes involved in arginine depletion, have been developed

Although our multivariate models successfully passed the Brant testconfirming that the proportional odds assumption was met and ensuring mathematical validitythis sample imbalance may still affect the ultimate stability and robustness of the regression estimates

its Phase II trial in ALS has recently concluded

Vamvakas, T