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[DOI] [PMC free article] [PubMed] [Google Scholar] 143.Tu J.Q., Liu H.P., Wen Y.H., Chen P., Liu Z.T

Clinical guidance recommends starting at ~50% of the usual starting dose with careful monitoring

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Abstract Barrett oesophagus (BE), the only known histological precursor of oesophageal adenocarcinoma (EAC), is a condition in which the squamous epithelium of the oesophagus is replaced by columnar epithelium as an adaptive response to gastro-oesophageal reflux

Notably, PH-related metabolic disturbances predominantly involve a shift from oxidative phosphorylation to aerobic glycolysisknown as the Warburg effectand systemic insulin resistance

It helps to regulate human body functions, such as cell multiplication, blood formation, and protein synthesis