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Peptide synthesis, cleavage, purification, counterion composition, residual solvent profile, moisture content, peptide content, endotoxin status, storage history, and freeze-thaw exposure can all affect what is actually introduced into a cell culture or preclinical model system

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These observations suggest that the mechanisms involved in humans may differ from the animal models

Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardsons syndrome

10.1021/acsabm.4c00888 110

Studies involving phantom test materials suggest that PRESS-acquired GSH may include oxidized GSH (GSSG) and that GSH edited MEGA-PRESS measurements give more precise values at lower GSH concentrations