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Therefore, as shown in Table 2, various types of nanoparticles including nanoemulsions/microemulsions, lipid nanoparticles, vesicular nanocarriers, polymeric nanoparticles, and gold nanoparticles were utilized to enhance skin permeation, improve drug solubility, increase photostability, control the drug release profile, induce longer drug deposition within the skin layers, and therefore enhance the clinical effectiveness of the therapeutic options for melasma treatment

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I hope I am wrong but it is precisely because it all looks to fit together so nicely (when it doesn't) that I am concerned

doi: 10.1016/j.envpol.2018.04.120 23 HuB.JinJ.GuoA

Fukami M, Maeda N, Fukushige J, Kogure Y, Shimada Y, Ogawa T, Tsujita Y

Antiviral action of ribavirin in chronic hepatitis C