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Moreover, the long non-coding RNA (lncRNA) SNHG14 affects SLC7A11 activity and prevents ferroptosis by targeting and downregulating miR-206 expression in nutlin3a-resistant osteosarcoma cell lines [174]

These initial observations indicate that organellar-specific expressions of ATPS and APK isoforms and formation of ATPS-APK protein complexes are key elements for flux partitioning of APS/PAPS biosynthesis and for S-sensing and signaling mechanisms

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