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Acknowledgements This work was supported by the National Science Foundation of China (21405071, 21535002, 21227008), Special Funds for the Construction of Taishan Scholars (grand No

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A growing body of evidence has reported that Nrf2 participates in regulating ferroptosis by promoting the expression of downstream genes[40], such as FTH1, SLC7A11, and HMOX1, most of which exert a negative regulatory effect against ferroptosis by promoting the synthesis of GSH, reducing ROS production, and upregulating NADPH expression

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A., Matot, E., Malka, G., Kosower, N., Rein, M., Zilberman-Schapira, G., Dohnalov, L., Pevsner-Fischer, M., Bikovsky, R., Halpern, Z., Elinav, E., & Segal, E