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doi: 10.1016/j.addr.2013.08.008 153 El OuaamariYVan den BosJWillekensBCoolsNWensI

Keywords: Dietary restriction, protein restriction, methionine restriction, lifespan extension Introduction Dietary restriction (DR) is an evolutionarily conserved strategy that was reported to extend lifespan in a broad range of organisms

Results from experimental studies have suggested that pharmacological doses of citicoline (CDP-choline) could enhance the metabolism of glucose and the biosynthesis of phospholipids and neurotransmitters, while limiting the degradation of phospholipids in neuronal membranes in models of ischemia and neurodegenerative diseases (reviewed in 92)

2003, 285: E1182-1195

doi: 10.1161/CIRCULATIONAHA.106.612325

I know that sounds like a wide range, but theres good reason for this variation
