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Since Fe 2+ in the labile iron pool is the specific substrate for ferroptosis, and rises with ageing in C

However, since small intestinal permeability was significantly higher in patients with alcoholic liver diseases than in patients with chronic alcohol abuse in the absence of liver disease, the direct barrier toxicity of alcohol does not fully account for the permeability defect (155)

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An uncontrolled, open-label trial in nine patients with probable Alzheimers disease and related dementias, who were also taking acetylcholinesterase inhibitors, reported that oral supplementation with 600 mg/day of lipoic acid appeared to stabilize cognitive function over a one-year period (101)

doi: 10.1001/jama.2010.1923 [DOI] [PMC free article] [PubMed] [Google Scholar] 30