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Biphalin, a dimeric enkephalin, alleviates LPS-induced activation in rat primary microglial cultures in opioid receptor-dependent and receptor-independent manners

Afshar H, Roohafza H, Mohammad-Beigi H, Haghighi M, Jahangard L, Shokouh P, et al

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The researchers propose that DSIPs observed effects, particularly the selective increase in V3 and ADP/t without affecting VDNP, suggest that it does not stimulate the activity of respiratory chain enzymes or substrate transporters, as these would typically affect VDNP

doi: 10.1038/nrrheum.2016.189 91 HauserWAlbrechtJBartramWUceylerNFurstDEFitzcharlesMAet al

At 52 weeks of continuous daily use, 34% of patients still had IGF-1 levels more than 2 standard deviations above their starting point meaning the downstream IGF-1 signal was still very much working a full year in