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GIP also activates an anti-nausea circuit in the brainstem, which helps offset some of the gastrointestinal burden created by GLP-1. GLP-1R: appetite, tolerability, and heart rate The GLP-1 arm carries appetite suppression, slower stomach emptying, most nausea, and part of the heart-rate signal

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This is because healthy levels of B12 can lower homocysteine

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[DOI] [PMC free article] [PubMed] [Google Scholar] 231.Muzik O, Mangner TJ, Leonard WR, Kumar A, Janisse J, Granneman JG

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