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GIP also activates an anti-nausea circuit in the brainstem, which helps offset some of the gastrointestinal burden created by GLP-1. GLP-1R: appetite, tolerability, and heart rate The GLP-1 arm carries appetite suppression, slower stomach emptying, most nausea, and part of the heart-rate signal

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[DOI] [PMC free article] [PubMed] [Google Scholar] 231.Muzik O, Mangner TJ, Leonard WR, Kumar A, Janisse J, Granneman JG

The lower abdomen (2 or more inches from the navel) is the most popular site due to fast absorption and low pain
