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In CBA/CaJ mice, females show increased mRNA expression of Nrf2 , a regulator of Phase II detoxification genes, and 9 genes involved in Phase II detoxification, including Gsta4 , compared to males

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GSH is oxidized to form GSSG, which can be reduced to GSH by the NADPH-dependent GR [28]

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Trends Endocrinol Metab 32:890903 Armstrong CW, McGregor NR, Lewis DP et al (2015) Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients