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Further, it has been reported that carrying the HP2 allele (alias, zonulin gene) correlates with higher risk of developing inflammatory diseases and HP2 homozygosis (two copied of the zonulin gene) is associated with increased morbidity

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While traditionally regarded as a vitamin B clearance enzyme, over the past decade NNMTs role has expanded dramaticallyto include reprogramming onecarbon metabolism, impacting NAD levels, DNA/histone methylation, and even tumor progression and angiogenesis