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The two major pathways for the degradation of proteins involve the selective elimination through the ubiquitin-proteasome system (UPS) and removal through chaperone-mediated autophagy (CMA) (128)

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Dihydroartemisinin enhances the inhibitory effect of sorafenib on HepG2 cells by inducing ferroptosis and inhibiting energy metabolism

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The safety record is generally placebo-like, but several specific findings deserve attention

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