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Introduction Although nitric oxide (NO) has been posited as a deleterious molecule from a physiological perspective ( In the context of exercise, nitrate supplementation has gained interest as an ergogenic aid to enhance endurance performance ( Therefore, the purpose of this review is to present the general knowledge of the underlying physiological mechanisms affected by NO and the subsequent effect of nitrate supplementation in exercise

Maintaining ROS homeostasis through the antioxidant system is essential for physiological functions, such as cell signaling, cellular function, and metabolic regulation (27)

The close association between neuroinflammation and neurodegeneration suggests that neuroinflammatory mechanisms may trigger neuronal degeneration, leading to neurotoxicity and a loss of neuronal cells

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MTFA33433-251009*

This shift is largely attributed to the expression of GLUT1 on the MDM cell surface, as MDMs lacking GLUT1 exhibit significantly diminished immune suppressive capabilities