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Vitamin B12 is the most chemically complex of all the vitamins, and cyanocobalamin and hydroxycobalamin are synthetically derived therapeutic forms of vitamin B12.6 Hydroxycobalamin protein binding capacity is greater than that of cyanocobalamin and both of them may cause allergic reactions.6 Vitamin B12 may lead to allergic reactions because of its cobalt molecule, molecular complexity or high molecular mass

Certain genetic disorders, such as sickle cell anemia and thalassemia, can result in abnormal red blood cell production or function

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Management should employ an MDT approach with obstetric input[1]