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We also speculate that the lack of stable cell lines could impact reproducibility of results

- Builds healthy immune response

This suggests that levels of free heme alone are not sufficient to immediately change the oxidative state of the parasite, although it is recognised that chemical inhibition of cysteine proteases may have additional impacts on the parasite, and does not perfectly mimic the heme depletion caused by K13-mediated alteration of hemoglobin uptake

Figure 3 3.1 Mitochondria: the initiation hub of ferroptosis Mitochondria serve as central regulators of metabolism and cell death, including ferroptosis (50)