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SpineWell
Polara, A
Free Radic Biol Med , 115: 92104, 2018
doi: 10.1016/j.biomaterials.2010.11.082
Third, we measured the chemical similarity between the generated molecules and the training set as quantified by the Frchet ChemNet distance 25
Kadcyla (T-DM1), in contrast, uses a non-cleavable thioether linker (DM1-SMCC) to release the payload DM1 through antibody degradation, effectively reducing off-target toxicity
