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Hyperestrogenism results in peristalsis of the myometrium which inflicts supraphysiological strain on cells at the fundo-cornual raphe (Leyendecker et al., 1998, 2004

Adult-onset calorie restriction attenuates kainic acid excitotoxicity in the rat hippocampal slice

This can gradually lighten pigmentation and even out tone

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Different insults induce brain tissue damage and lead to neuronal cell death such as ischemic injury, oxidative stress, and glutamate toxicity (Figure 4)