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DOI: 10.4103/1673-5374.320969

(1) Overview Epithalon is a synthetic tetrapeptide, also known as AEDG peptide, composed of amino acids Ala-Glu-Asp-Gly

10.1016/j.abb.2008.09.016 94 SharmaR.SharmaA.DwivediS.ZimniakP.AwasthiS.AwasthiY

PE-22-28 (Mini-Spadin) blocks TREK-1 potassium channels with ~100-fold greater potency than its parent compound, demonstrating BDNF upregulation, rapid neurogenesis within 4 days, and cognitive benefits in stroke models (Djillani et al., 2017 in Frontiers in Pharmacology)

There is some limited support for other effects, but more research is needed

Fractional lasers treat a percentage, or fraction, of the skin in the treatment area