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It was also demonstrated that the kava extract induces CYP1A1 expression in a concentration-dependent manner, especially due to methysticin, but also 7,8-dihydromethysticin [50]

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Epigallocatechin gallate (EGCG) is a highly abundant polyphenol in green tea

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Upon tumor necrosis factor-alpha (TNF-) stimulation, TNFR1 undergoes a conformational change that facilitates the recruitment of several adaptor proteins to form membrane-bound signaling complex I, consisting of TNFR1-associated death domain protein (TRADD), RIPK1, TNF receptorassociated factor 2 (TRAF2), and the cellular inhibitors of apoptosis (cIAP1/2) to form membrane-associated complex I (14)