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Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3

Additionally, ROS can also induce DNA damage leading to mutagenesis in nucleobases like guanine and can ultimately lead to tumor-initiating events 65
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PMCID: PMC6153947

You might think you're administering a 1mg dose, but in reality, you're administering a fraction of that, along with a cocktail of unknown degradants

Li C, Li X, Chen W et al (2007) The different roles of cyclinD1-CDK4 in STP and mGluR-LTD during the postnatal development in mice hippocampus area CA1
