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Keywords: Metformin, Vitamin B12 deficiency, Metformin-induced cobalamin deficiency, Diabetes, Type 2 diabetes, Prediabetes, Screening criteria, Neuropathy, Anemia Core Tip: Over the last decades, vitamin B12 deficiency has been increasingly recognized as a possible consequence of long-term metformin therapy, potentially resulting in clinical manifestations such as hematologic abnormalities and peripheral neuropathy