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Several clinical studies and meta-analyses have quantified the effects of EPO and high-altitude exposure on hemoglobin concentration and erythropoietic response, highlighting significant individual variability and the potential risks of excessive EPO use, such as increased hematocrit and cardiovascular complications, emphasizing the need for controlled usage and monitoring (Poszczyca et al., 2018

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In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy

These can include minor allergic reactions, such as skin rashes or itching, but such responses typically resolve on their own without intervention

J Biol Chem 281(9):56575667

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