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In addition to durability, NA provides rapid, NIR-triggered on-demand cisplatin release (70% in 5 min) and prevents premature leakage, offering spatial and temporal control

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While dietary supplements are less tightly regulated than drugs, the FDA still requires them to only contain ingredients found on a list of approved substances

Irinotecan can be activated by carboxylesterase 1/2 (CES1/2) and catalyzed to a more active metabolite SN-38, both of which could form an inhibitory complex with TOP1 and DNA (Takano and Sugiyama, 2017)

Penn State University conducted a 2-week human study using Tri-Fortify to assess changes in intracellular glutathione absorption (not just plasma levels)
