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After receiving the patients informed consent, we began the following treatment in July 2019: Combined therapy with oral antioxidants propolis 700 mg + bilberry 180 mg + silymarin 400 mg + ginkgo biloba 240 mg + L-carnitine 1000 mg + coenzyme Q10 100 mg + Boswellia 200 mg + vitamin E 48 mg + vitamin C 50 mg + superoxide dismutase 11,000 IU/g 10 mg/daily + topical diclofenac gel 4%/2 daily + peri-plaque penile injection of pentoxifylline 100 mg with 30 G needle every month for 12 months