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Guilhen C, Forestier C, Balestrino D

Mitochondrial dysfunction is characterized by various degrees of ultrastructural mitochondrial damage, abnormal morphologic changes, increased permeability of the outer and inner membranes, impaired mitochondrial -oxidation, respiratory chain activity reduction, ROS overproduction, ATP depletion, and oxidative stress-mediated deletions of mtDNA inducing apoptosis (Ramanathan et al

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Trastuzumab emtansine plus pertuzumab versus taxane plus trastuzumab plus pertuzumab after anthracycline for high-risk human epidermal growth factor receptor 2-positive early breast cancer: the phase III KAITLIN study