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The collagen story is really a remodeling story The first clean fibroblast result landed in 1988, when Maquart and colleagues reported in FEBS Letters that GHK-Cu pushed cultured skin fibroblasts to make more collagen at concentrations as low as 10 M
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This artifact is especially common in rats that are not exsanguinated at necropsy and the cytoplasmic vacuoles represent plasma influx into to affected cells (Figure 33 )
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[DOI] [PMC free article] [PubMed] 49.Tan CH, Wu Y, Satkunanantham M
