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Gut microbes metabolize carnitine into trimethylamine (TMA) [13], which is absorbed by enterocytes and converted into trimethylamine-N-oxide (TMAO) in the liver [14]

However, the majority of TMAO is excreted unchanged in the urine within 24 hours, with only a small amount excreted in the feces (72) ( Figure 1 )

L-Carnitine supports heart health through several mechanisms: Energy Production and Heart Function: L-Carnitine is crucial for fatty acid oxidation, which is a primary energy source for the heart muscle

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And researchers recommend zinc supplementation to treat addiction and reduce withdrawal symptoms (70, 71)

A practical 12 week protocol used by many clinicians and reflected in research is: Weeks 0 to 2 Start with one gram daily, taken with a carbohydrate containing meal or after exercise