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Because these reactions were reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency, reliability, or to establish a causal relationship to drug exposure

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Bruls YM, de Ligt M, Lindeboom L, Phielix E, Havekes B, Schaart G, et al

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Nasca C, Rasgon N, McEwen B (2019) An emerging epigenetic framework of systemic and central mechanisms underlying stress-related disorders