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However, inhibition of PGE 2 -EP2 only reduces demyelination when started at the same time as cuprizone treatment, not when started during peak demyelination suggesting a role for PG during the initiation of demyelination (Fig

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References Published with license by Science and Education Publishing, Copyright 2020 Salah Mohamed El Sayed, Elsayed Abdelkreem, Moutasem Salih Aboonq, Sultan S

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The practical approach is to reconstitute your first vial, use it through weeks 1 to 4 (drawing only 1.0 mg total), then continue into weeks 5 to 8 from the same reconstituted vial