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Data extraction and analysis All identified studies were independently reviewed by two authors (O.S

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The assumption that nitric oxide inhibits mitochondrial ATP synthesis is correct

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This context dependence also suggests that, when applying BCAA-related targets for disease intervention, it is necessary to distinguish between two different levels of regulatory modes: the mTOR-driven pro-inflammatory effects caused by enhanced BCAA uptake/transport, and the support provided by changes in BCAA catabolic flux to mitochondrial metabolism and reparative programs, so as to avoid conflating results obtained from different experimental systems

Glutathione supports anti-ageing too