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Classically activated M1 macrophages, associated with pro-inflammatory functions, are often elevated in colonic tissues, releasing inflammatory mediators that exacerbate the inflammatory environment

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In so doing, it will also hopefully open the doors to new diagnostics and therapeutics

Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe / mice

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59 Altogether, there is significant variability and inconsistency in the literature surrounding the role of iron in macrophage polarization, likely due to variability in initial polarization state, origin of the macrophages, and length of treatments
